“Let food by thy medicine and medicine be thy food”
Turmeric (Curcuma longa) is native to Southeast Asia and tropical India and its traditional use in Asian curries serves both to create the unique flavour and helps prevent microbial growth in hot tropical climates while supporting health in numerous ways. Today, Turmeric is one of the most well researched medicinal plants in the world with tremendous focus on its unique antioxidant properties.
Nanotechnology in herbal medicine has allowed for improved bioavailablity and this is especially important for the active ingredients in Turmeric, the curcuminoids such as Curcumin, which have low bioavailablity in capsules and tablets. The main absorbtion issue with Curcumin is the degradation in the gut and as a result much of the ingested Curcumin is broken down in digestion and eliminated in the urine. Nano Curcumin Elixir is in a water-soluble colloidal suspension form that is rapidly absorbed, allowing for many times enhanced bioavailability of Curcumin.
Nano Curcumin Elixir has been specially formulated to have a mild acceptable taste allowing for greater convenience for both kids and the elderly, an important development not found in bitter or “curry powder” tasting Turmeric liquid preparations. Because of its safety and efficacy being confirmed in more than 8000 scientific studies Curcumin or Turmeric is considered one of the safest and most important functional foods / medicinal herbs in the world.
Nano Curcumin is recommended to support antioxidant health at any time, especially:
- As a preventative for chronic disease and cancers
- After consuming junk foods or excessively fried foods
- During increased stress
- For smokers
- For drinkers and to prevent hangovers
- To prevent colds and flus and much more!
Nano Curcumin Elixir is
- Fully water-soluble colloidal emulsion
- 100% vegetarian / vegan ingredients
- Free from alcohol
- Free from artificial flavours and colours
- Free of Polyethylene glycol (PEG), propylene glycol (PG) and chemical additives
- Free from genetically modified ingredients
How much to take?
Adults: At least 6 – 10 drops to a glass of water or any drink and stir thoroughly. May be taken several times daily.
Children (between 6 to 12 years): 3 -5 drops added to water or juice.
Each bottle contains: 120mls for a 1-2 months supply
Liquid nano-concentrate of Curcuma longa (Turmeric Root)
Other ingredients: Purified Water, Gum Acacia, Potassium Sorbate, Citric Acid.
Curcuma longa & Curcumin Research Focus:
ANTIOXIDANT & ANTI-CANCER
Numerous studies have also shown the cancer preventing action of curcumin in multiple cancers with an additional increase in the complementary cancer-killing effects of radiotherapy and chemotherapy. Every month more than a dozen new studies are published in scientific journals making this one of the most well-researched antioxidant and anti-cancer herbs in the world. For links to some of these studies, please click here.
OXIDATIVE STRESS AND INFLAMMATORY CONDITIONS:
Research has found that Curcumin reduces inflammation and assists healing in the following conditions: Diabetes Mellitus Type 2, Radiation, Inflammatory Bowel Disease, Cholestasis, Aflatoxicosus, Osteoarthritis, High Cholesterol, Irritable Bowel Syndrome (IBS), Colon Polyps, Asthma, Rheumatoid Arthritis, Myocardial Ischemia, Ulcerative Colitis, Arthritis, Allergies, Allergies, Cystic Fibrosis, Inflammatory Bowel Disease (IBD), Crohns Disease, Post Surgical Inflammation and conditions that are normally prescribed anti-inflammatory drugs, corticosteroids and antihistamines.
Traditionally in Asia, Turmeric is used for indigestion, jaundice, liver and gallbladder disorders. Studies have shown that curcumin possesses properties that protect the liver from a number of toxic compounds. Turmeric is helpful to prevent gallbladder disease, however it should be used with caution in gallstones because of its positive effects on increasing bile flow. Liver damage due to alcohol and food poisoning was also reversed. In a double blind study in Thailand, Turmeric was studies for its effects on relieving indigestion and gas. An impressive 87 percent of patients receiving Curcuma responded positively to the treatment, which resulted in several patent medicines for indigestion containing standardized curcumin being developed. Turmeric also contains natural compounds that act as a natural antacid, protecting the stomach lining from excess acidity and ulcer formation.
Turmeric has also been shown to reduce platelets (a constituent of the blood involved in blood clotting) from clumping together, which in turn improves circulation and helps protect against atherosclerosis. Several studies have shown that a daily oral administration of Turmeric extract decreases significantly the LDL (bad cholesterol) and increases the HDL (good cholesterol) of healthy subjects. All the researchers concluded that Turmeric is useful in the management of atherosclerosis and cardiovascular disease.
IMMUNITY AND INFECTIOUS CONDITIONS
Numerous cancer research institutes, including the Amala Cancer Research Centre in India have confirmed that curcumin significantly increased several parameters of immune activity in improving infection fighting and anti-tumor activity. Researchers have also initiated some studies on curcumin use for HIV infection, where it is found to have marked anti-HIV properties in the test tube. It was also found to protect from the subsequent infections from weakened immunity, such as Epstein-Barr virus (EBV). Other immune related and anti-infective conditions benefited by Curcumin include: Low Immunity, Malaria, Helicobacter Pylori Infection, Fungal Infection, Parasitic Diseases, Liver Flukes, Automimmune Diseases, Bacterial Infections, Candida, Respiratory Tract Infections, Tuberculosis, Vitiligo.
PROTECTION FROM DIABETES
Curcumin is one of the most exciting novel ingredients being researched globally for its effects on preventing impaired glucose tolerance and insulin resistance. Click here for more scientific information on Curcumin and Diabetes research.
NERVOUS SYSTEM AND NEURO-DEGENERATIVE CONDITIONS
A large body of evidence is showing that Curcumin can cross the blood brain barrier and protect from a range of neurodegenerative diseases, including Alzheimers Disease. Additional nervous system conditions benefited by Curcumin include: Memory Disorders, Brain Ischemia, Dementia, Multiple Sclerosis, Parkinsons, Brain Damage, Epilepsy, Depression, Cognitive Decline, Aging Brain, Stress, Spinal Cord Injuries & Anxiety Disorders.
Scientific Research on Turmeric and Curcumin has focused on the following diseases (click to open):
- Anxiety disorders
- Alzheimer’s disease
- Prevention of amyloid plaques
- Post traumatic stress disorder (PTSD)
- Heavy metal / toxic metal chelation; cadmium, lead & aluminium
- Neurological protection
- Cerebral ischemia
- Protection from brain damage
- Multiple cancers and tumor formation
- Alleviating side effects of cancer chemo- and radiotherapy
Antioxidant & Anti-inflammatory
- Oxidative stress
- Arthritis, osteoarthritis and inflammatory joint conditions
- Diabetes and diabetic retinopathy
- Asthma amelioration
Liver and Digestion
- Liver disease
- Gastric function and prevention of Helicobacter pylori
- Protection from alcohol toxicity
- Inflammatory bowel disease
Heart & Circulation
- Healthy cholesterol regulation
Immunity & Healing:
- Respiratory infections
- Disease resistance
- Wound healing
- Inflammatory skin conditions, e.g. psoriasis, eczema
Links to Research Studies on Nano Curcumin
Turmeric along with it’s principle active ingredient Curcumin is one of the most exhaustively studied medicinal plants in the world with more than 8,000 published studies in scientific journals. Much of the recent studies have been focused on ways to improve the bioavailability of Curcumin through incorporating advances in nanotechnology for enhanced drug delivery and to overcome the issue of the low bioavailability of Curcumin. The most recent studies are given below and these form the basis of the development of Nano Curcumin Elixir, please click to view the study abstracts below.
- Short peptide based nanotubes capable of effective curcumin delivery for treating drug resistant malaria. Alam S, Panda JJ, et al. J Nanobiotechnology. 2016 Apr 5;14(1):26. doi: 10.1186/s12951-016-0179-8.
- A comparative study of curcumin-loaded lipid-based nanocarriers in the treatment of inflammatory bowel disease. Beloqui A, Memvanga PB, Et al. Colloids Surf B Biointerfaces. 2016 Mar 16;143:327-335. doi: 10.1016/j.colsurfb.2016.03.038. [Epub ahead of print]
- Dextran based nanosized carrier for the controlled and targeted delivery of curcumin to liver cancer cells. Anirudhan TS, Binusreejayan. Int J Biol Macromol. 2016 Mar 21;88:222-235. doi: 10.1016/j.ijbiomac.2016.03.040.
- Curcumin Nanoformulation for Cervical Cancer Treatment. Zaman MS, Chauhan N, Et al. Sci Rep. 2016 Feb 3;6:20051. doi: 10.1038/srep20051.
- pH-sensitive micelles based on acid-labile pluronic F68-curcumin conjugates for improved tumor intracellular drug delivery. Fang XB, Zhang JM Et al. Int J Pharm. 2016 Apr 11;502(1-2):28-37. doi: 10.1016/j.ijpharm.2016.01.029.
- Enhancement of Curcumin Solubility by Phase Change from Crystalline to Amorphous in Cur-TPGS Nanosuspension. Shin GH, Li J, Cho JH, Kim JT, Park HJ. J Food Sci. 2016 Feb;81(2):N494-501. doi: 10.1111/1750-3841.13208.
- Enhanced anti-cancer and antimicrobial activities of curcumin Adahoun MA, Al-Akhras MH, Jaafar MS, Bououdina M. Artif Cells Nanomed Biotechnol. 2016 Jan 8:1-10.
- Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems. Ndong Ntoutoume GM, Granet R Et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):941-5. doi: 10.1016/j.bmcl.2015.12.060.
- Acetal-linked polymeric prodrug micelles for enhanced curcumin Li M, Gao M Et al Colloids Surf B Biointerfaces. 2016 Apr 1;140:11-8. doi: 10.1016/j.colsurfb.2015.12.025. Epub 2015 Dec 18.
- The Design of Amphiphilic Polymeric Micelles of Curcumin for Cancer Management. Liu M, Du H, Zhai G. Curr Med Chem. 2015;22(38):4398-411.
- Enhanced Therapeutic Potential of Nano–Curcumin Against Subarachnoid Hemorrhage-Induced Blood-Brain Barrier Disruption Through Inhibition of Inflammatory Response and Oxidative Stress. Zhang ZY, Jiang M, Fang J Et al. Mol Neurobiol. 2015 Dec 26.
- The next generation cell-penetrating peptide and carbon dot conjugated nano-liposome for transdermal delivery of curcumin. Patra S, Roy E, Madhuri R, Sharma PK. Biomater Sci. 2016 Feb 23;4(3):418-29. doi: 10.1039/c5bm00433k.
- Curcumin induces apoptosis by inhibiting sarco/endoplasmic reticulum Ca(2+) ATPase activity in ovarian cancer cells. Seo JA, Kim B, Et al. Cancer Lett. 2016 Feb 1;371(1):30-7. doi: 10.1016/j.canlet.2015.11.021.
- Nano–curcumin prepared via supercritical: Improved anti-bacterial, anti-oxidant and anti-cancer efficacy. Xie M, Fan D Et al. Int J Pharm. 2015 Dec 30;496(2):732-40.
- Curcumin and tumor immune-editing: resurrecting the immune system. Bose S, Panda AK, Mukherjee S, Sa G. Cell Div. 2015 Oct 12;10:6. doi: 10.1186/s13008-015-0012-z. eCollection 2015. Review.
- Hyaluronic acid-conjugated polyamidoamine dendrimers for targeted delivery of 3,4-difluorobenzylidene curcumin to CD44 overexpressing pancreatic cancer cells. Kesharwani P, Et al. Colloids Surf B Biointerfaces. 2015 Dec 1;136:413-23. doi: 10.1016/j.colsurfb.2015.09.043.
- Gum arabic-curcumin conjugate micelles with enhanced loading for curcumin delivery to hepatocarcinoma cells. Sarika PR, James NR Et al. Carbohydr Polym. 2015 Dec 10;134:167-74.
- Effect of polymer architecture on curcumin encapsulation and release from PEGylated polymer nanoparticles: Toward a drug delivery nano-platform to the CNS. Rabanel JM, Faivre J,Et al. Eur J Pharm Biopharm. 2015 Oct;96:409-20.
- Curcumin loaded self assembled lipid-biopolymer nanoparticles for functional food applications. Pathak L, Kanwal A, Agrawal Y. J Food Sci Technol. 2015 Oct;52(10):6143-56.
- Curcumin enhances poly(ADP-ribose) polymerase inhibitor sensitivity to chemotherapy in breast cancer cells. Choi YE, Park E. J Nutr Biochem. 2015 Dec;26(12):1442-7.
- Characterization and biological properties of NanoCUR formulation and its effect on major human cytochrome P450 enzymes. Shamsi S, Chen Y, Lim LY. Int J Pharm. 2015 Nov 10;495(1):194-203.
- Hyaluronic Acid Engineered Nanomicelles Loaded with 3,4-Difluorobenzylidene Curcumin for Targeted Killing of CD44+ Stem-Like Pancreatic Cancer Cells. Kesharwani P, Banerjee S Et al. Biomacromolecules. 2015 Sep 14;16(9):3042-53.
- Experimental investigation and oral bioavailability enhancement of nano-sized curcumin by using supercritical anti-solvent process. Anwar M, Ahmad I Et al, Eur J Pharm Biopharm. 2015 Oct;96:162-72.
- Polymerized nano–curcumin attenuates neurological symptoms in EAE model of multiple sclerosis through down regulation of inflammatory and oxidative processes and enhancing neuroprotection and myelin Mohajeri M, Sadeghizadeh M, Et al. Neuropharmacology. 2015 Dec;99:156-67. doi: 10.1016/j.neuropharm.2015.07.013. Epub 2015 Jul 23.
- Targeted nanomedicine for prostate cancer therapy: docetaxel and curcumin co-encapsulated lipid-polymer hybrid nanoparticles for the enhanced anti-tumor activity in vitro and in vivo. Yan J, Wang Y, Et al. Drug Deliv. 2015 Jul 27:1-6.
- Self-carried curcumin nanoparticles for in vitro and in vivo cancer therapy with real-time monitoring of drug release. Zhang J, Li S, Et al. 2015 Aug 28;7(32):13503-10.
- Controlled morphology and size of curcumin using ultrasound in supercritical CO2 antisolvent. Jia J, Wang W, Gao Y, Zhao Y. Ultrason Sonochem. 2015 Nov;27:389-94.
- Introducing Dendrosomal Nanocurcumin as a Compound Capable of in vitro Eliminating Undifferentiated Stem Cells in Cell Therapy Practices. Javidi MA, Zolghadr F, Et al. Exp Clin Endocrinol Diabetes. 2015 Nov;123(10):632-6.
- Cost-effective alternative to nano-encapsulation: Amorphous curcumin-chitosan nanoparticle complex exhibiting high payload and supersaturation generation. Nguyen MH, Yu H, Et al. Eur J Pharm Biopharm. 2015 Oct;96:1-10.
- Curcumin loaded pH-sensitive hybrid lipid/block copolymer nanosized drug delivery systems. Jelezova I, Drakalska E, Et al. Eur J Pharm Sci. 2015 Oct 12;78:67-78. doi: 10.1016/j.ejps.2015.07.005.
- Amphiphilic zein hydrolysate as a novel nano-delivery vehicle for curcumin. Wang YH, Et al. Food Funct. 2015 Aug;6(8):2636-45. doi: 10.1039/c5fo00422e.
- The mechanism of self-assembled mixed micelles in improving curcumin oral absorption: In vitro and in vivo. Wang J, Ma W, Tu P. Colloids Surf B Biointerfaces. 2015 Sep 1;133:108-19. doi: 10.1016/j.colsurfb.2015.05.056.
- Polymer-Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells. Mancarella S, Et al. Macromol Biosci. 2015 Oct;15(10):1365-74. doi: 10.1002/mabi.201500142.
- Parenterally administrable nano-micelles of 3,4-difluorobenzylidene curcumin for treating pancreatic cancer. Kesharwani P, Et al. Colloids Surf B Biointerfaces. 2015 Aug 1;132:138-45. doi: 10.1016/j.colsurfb.2015.05.007.
- Dendrosomal curcumin suppresses metastatic breast cancer in mice by changing m1/m2 macrophage balance in the tumor microenvironment. Shiri S, Alizadeh AM, Et al. Asian Pac J Cancer Prev. 2015;16(9):3917-22.
- Synergistically Improved Anti-tumor Efficacy by Co-delivery Doxorubicin and Curcumin Polymeric Micelles. Wang J, Ma W, Tu P. Macromol Biosci. 2015 Sep;15(9):1252-61. doi: 10.1002/mabi.201500043.
- Preparation, characterization and in vivo evaluation of curcumin self-nano phospholipid dispersion as an approach to enhance oral bioavailab Allam AN, Et al. Int J Pharm. 2015 Jul 15;489(1-2):117-23. doi: 10.1016/j.ijpharm.2015.04.067.
- Poly(D,L-lactic acid)-glycerol-based nanoparticles for curcumin Yoon IS, Et al. Int J Pharm. 2015 Jul 5;488(1-2):70-7. doi: 10.1016/j.ijpharm.2015.04.046.
- Study of curcumin behavior in two different lipid bilayer models of liposomal curcumin using molecular dynamics simulatio Jalili S, Saeedi M. J Biomol Struct Dyn. 2016 Feb;34(2):327-40. doi: 10.1080/07391102.2015.1030692.
- Magnetic high throughput screening system for the development of nano-sized molecularly imprinted polymers for controlled delivery of curcumin. Piletska EV, Et al. 2015 May 7;140(9):3113-20. doi: 10.1039/c4an02292k.
- Curcumin, encapsulated in nano-sized PLGA, down-regulates nuclear factor κB (p65) and subarachnoid hemorrhage induced early brain injury in a rat model. Chang CZ, Et al. Brain Res. 2015 May 22;1608:215-24. doi: 10.1016/j.brainres.2015.02.039.
- Biodegradable m-PEG/PCL Core-Shell Micelles: Preparation and Characterization as a Sustained Release Formulation for Curcumin. Danafar H, Et al. Adv Pharm Bull. 2014 Dec;4(Suppl 2):501-10. doi: 10.5681/apb.2014.074.
- Effect of curcumin caged silver nanoparticle on collagen stabilization for biomedical applications. Srivatsan KV, Et al. Int J Biol Macromol. 2015 Apr;75:306-15. doi: 10.1016/j.ijbiomac.2015.01.050.
- Future of nano bisdemethoxy curcumin analog: guaranteeing safer intravenous delivery. Francis AP, Et al. Environ Toxicol Pharmacol. 2015 Jan;39(1):467-74. doi: 10.1016/j.etap.2014.12.018.
- Simple analytical strategy for MALDI-TOF-MS and nanoUPLC-MS/MS: quantitating curcumin in food condiments and dietary supplements and screening of acrylamide-induced ROS protein indicators reduced by curcumin. Huang YS, Hsieh TJ, Lu CY. Food Chem. 2015 May 1;174:571-6. doi: 10.1016/j.foodchem.2014.11.115.
- Curcumin encapsulated pH sensitive gelatin based interpenetrating polymeric network nanogels for anti cancer drug delivery. Madhusudana Rao K Et al. Int J Pharm. 2015 Jan 30;478(2):788-95. doi: 10.1016/j.ijpharm.2014.12.001.
- Comparative anti-inflammatory potential of crystalline and amorphous nano curcumin in topical drug delivery. Al-Rohaimi AH. J Oleo Sci. 2015;64(1):27-40. doi: 10.5650/jos.ess14175.
- Nano metal-organic framework (NMOF)-based strategies for multiplexed microRNA detection in solution and living cancer cells. Wu Y, Han J, Xue P, Xu R, Kang Y. Nanoscale. 2015 Feb 7;7(5):1753-9. doi: 10.1039/c4nr05447d.
- Hybrid curcumin compounds: a new strategy for cancer treatment. Teiten MH, Dicato M, Diederich M. Molecules. 2014 Dec 12;19(12):20839-63. doi: 10.3390/molecules191220839. Review.
- Nanoparticle-mediated dual delivery of an antioxidant and a peptide against the L-Type Ca2+ channel enables simultaneous reduction of cardiac ischemia-reperfusion injury.Hardy N, Et al. ACS Nano. 2015 Jan 27;9(1):279-89. doi: 10.1021/nn5061404.
- Inhibition of osteoclast differentiation by gold nanoparticles functionalized with cyclodextrin curcumin Heo DN, Ko WK, Et al. ACS Nano. 2014 Dec 23;8(12):12049-62. doi: 10.1021/nn504329u.
- Oral administration of nano-emulsion curcumin in mice suppresses inflammatory-induced NFκB signaling and macrophage migration. Young NA, Et al. PLoS One. 2014 Nov 4;9(11):e111559. doi: 10.1371/journal.pone.0111559. eCollection 2014.
- (Copper-curcumin) β-cyclodextrin vaginal gel: delivering a novel metal-herbal approach for the development of topical contraception prophylaxis. Gaurav C, Et al. Eur J Pharm Sci. 2014 Dec 18;65:183-91. doi: 10.1016/j.ejps.2014.09.019.
- Thermo-responsive release of curcumin from micelles prepared by self-assembly of amphiphilic P(NIPAAm-co-DMAAm)-b-PLLA-b-P(NIPAAm-co-DMAAm) triblock copolymers. Hu Y, Darcos V, Monge S, Et al. Int J Pharm. 2014 Dec 10;476(1-2):31-40. doi: 10.1016/j.ijpharm.2014.09.029.
- Solubility enhancement and delivery systems of curcumin a herbal medicine: a review. Hani U, Shivakumar HG. Curr Drug Deliv. 2014;11(6):792-804. Review.
- Preparation and characterization of bionanoemulsions for improving and modulating the antioxidant efficacy of natural phenolic antioxidant curcumin. Malik P, Ameta RK, Singh M. Chem Biol Interact. 2014 Aug 7;222C:77-86. doi: 10.1016/j.cbi.2014.07.013.
- Protective action of curcumin and nano–curcumin against arsenic-induced genotoxicity in rats in vivo. Sankar P, Et al. Mol Biol Rep. 2014 Nov;41(11):7413-22. doi: 10.1007/s11033-014-3629-0.
- Preparation of curcumin micelles and the in vitro and in vivo evaluation for cancer therapy. Li X, Et al. J Biomed Nanotechnol. 2014 Aug;10(8):1458-68.
- pH-sensitive nanoparticles for colonic delivery of curcumin in inflammatory bowel disease. Beloqui A, Coco R, Et al. Int J Pharm. 2014 Oct 1;473(1-2):203-12. doi: 10.1016/j.ijpharm.2014.07.009.
- Targeting cancer with nano-bullets: curcumin, EGCG, resveratrol and quercetin on flying carpets. Aras A, Et al. Asian Pac J Cancer Prev. 2014;15(9):3865-71. Review.
- Design of novel multifunctional targeting nano-carrier drug delivery system based on CD44 receptor and tumor microenvironment pH condition. Chen D, Lian S, Et al. Drug Deliv. 2016 Mar;23(3):808-13. doi: 10.3109/10717544.2014.917130.
- Recent advances in curcumin nanoformulation for cancer therapy. Lee WH, Loo CY, Et al. Expert Opin Drug Deliv. 2014 Aug;11(8):1183-201. doi: 10.1517/17425247.2014.916686.
- Epigenetic impact of curcumin on stroke prevention. Kalani A, Et al. Metab Brain Dis. 2015 Apr;30(2):427-35. doi: 10.1007/s11011-014-9537-0.
- Curcumin-primed exosomes mitigate endothelial cell dysfunction during hyperhomocysteinemia. Kalani A, Et al. Life Sci. 2014 Jun 27;107(1-2):1-7. doi: 10.1016/j.lfs.2014.04.018. Epub 2014 Apr 26.
- Bis-demethoxy curcumin analog nanoparticles: synthesis, characterization, and anticancer activity in vitro. Francis AP, Murthy PB, Devas T. J Nanoscience Nanotechnology. 2014 Jul;14(7):4865-73.
- Synthesis and in vitro localization study of curcumin-loaded SPIONs in a micro capillary for simulating a targeted drug delivery Anwar M, Et al. Int J Pharm. 2014 Jul 1;468(1-2):158-64. doi: 10.1016/j.ijpharm.2014.04.038.
- Simple and effective preparation of nano-pulverized curcumin by femtosecond laser ablation and the cytotoxic effect on C6 rat glioma cells in vitro. Tagami T, Imao Y, Et al. Int J Pharm. 2014 Jul 1;468(1-2):91-6. doi: 10.1016/j.ijpharm.2014.04.013.
- Curcumin-cyclodextrin encapsulated chitosan nanoconjugates with enhanced solubility and cell cytotoxicity. Popat A, Et al. Colloids Surf B Biointerfaces. 2014 May 1;117:520-7. doi: 10.1016/j.colsurfb.2014.03.005.
- Preparation of novel curcumin-loaded multifunctional nanodroplets for combining ultrasonic development and targeted chemotherapy. Ji G, Yang J, Chen J. Int J Pharm. 2014 May 15;466(1-2):314-20. doi: 10.1016/j.ijpharm.2014.03.030.
- Curcumin and 5-fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia. Balasubramanian S, Et al. Int J Nanomedicine. 2014 Jan 9;9:437-59. doi: 10.2147/IJN.S49882.
- Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Prasad S, Tyagi AK, Aggarwal BB. Cancer Res Treat. 2014 Jan;46(1):2-18. doi: 10.4143/crt.2014.46.1.2. Epub 2014 Jan 15. Review.
- Ensemble docking and molecular dynamics identify knoevenagel curcumin derivatives with potent anti-EGFR activity. Yadav IS, Et al. Gene. 2014 Apr 10;539(1):82-90. doi: 10.1016/j.gene.2014.01.056.
- Nanocurcumin: a novel antifilarial agent with DNA topoisomerase II inhibitory activity. Ali M, Afzal M, Abdul Nasim S, Ahmad I. J Drug Target. 2014 Jun;22(5):395-407.
- Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer’s disease model via canonical Wnt/β-catenin pathway. Tiwari SK, Et al. ACS Nano. 2014 Jan 28;8(1):76-103. doi: 10.1021/nn405077y. Epub 2013 Dec 10.
- The anti-tumor efficacy of curcumin when delivered by size/charge-changing multistage polymeric micelles based on amphiphilic poly(β-amino ester) derivates. Yu Y, Zhang X, Qiu L. 2014 Mar;35(10):3467-79. doi: 10.1016/j.biomaterials.2013.12.096.
- Curcumin nanoformulations: a review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment. Naksuriya O, Et al. Biomaterials. 2014 Mar;35(10):3365-83. doi: 10.1016/j.biomaterials.2013.12.090.
- Nanoparticles with dual responses to oxidative stress and reduced ph for drug release and anti-inflammatory applications. Pu HL, Chiang WL, Et al. ACS Nano. 2014 Feb 25;8(2):1213-21. doi: 10.1021/nn4058787.
- Effects of nanoparticle-encapsulated curcumin on arsenic-induced liver toxicity in rats. Sankar P, Et al. Environ Toxicol. 2015 May-Jun;30(6):628-37. doi: 10.1002/tox.21940. Epub 2013 Dec 18.
- CNS delivery and pharmacokinetic evaluations of DALDA analgesic peptide analog administered in Nano-sized oil-in-water emulsion formulation. Shah L, Gattacceca F, Amiji MM. Pharm Res. 2014 May;31(5):1315-24. doi: 10.1007/s11095-013-1252-8. Epub 2013 Dec 3.
- Anti-inflammatory potency of nano-formulated puerarin and curcumin in rats subjected to the lipopolysaccharide-induced inflammation. Singh AK, Jiang Y, Et al. J Med Food. 2013 Oct;16(10):899-911. doi: 10.1089/jmf.2012.0049.
- Curcumin loaded poly(2-hydroxyethyl methacrylate) nanoparticles from gelled ionic liquid–in vitro cytotoxicity and anti-cancer activity in SKOV-3 cells. Kumar SS, Et al. Eur J Pharm Sci. 2014 Jan 23;51:34-44. doi: 10.1016/j.ejps.2013.08.036.
- Design and in vitro evaluation of a new nano-microparticulate system for enhanced aqueous-phase solubility of curcumin. Guzman-Villanueva D, Et al. Biomed Res Int. 2013;2013:724763. doi: 10.1155/2013/724763.
- Nano-transfersomes as a novel carrier for transdermal delivery. Chaudhary H, Kohli K, Kumar V. Int J Pharm. 2013 Sep 15;454(1):367-80. doi: 10.1016/j.ijpharm.2013.07.031.
- Synergetic effect of SLN-curcumin and LDH-5-Fu on SMMC-7721 liver cancer cell line. Zhu R, Et al. Cancer Biother Radiopharm. 2013 Oct;28(8):579-87. doi: 10.1089/cbr.2012.1445. Epub 2013 Jun 29.
- Superior anticancer efficacy of curcumin-loaded nanoparticles against lung cancer. Yin H, Zhang H, Liu B. Acta Biochim Biophys Sin (Shanghai). 2013 Aug;45(8):634-40. doi: 10.1093/abbs/gmt063.
- Nano–curcumin inhibits proliferation of esophageal adenocarcinoma cells and enhances the T cell mediated immune Milano F, Mari L, Et al. Front Oncol. 2013 May 29;3:137. doi: 10.3389/fonc.2013.00137.
- Towards scale-up and regulatory shelf-stability testing of curcumin encapsulated polyester nanoparticles. Grama CN, Et al. Drug Deliv Transl Res. 2013 Jun;3(3):286-93. doi: 10.1007/s13346-013-0150-2.
- Oily nanosuspension for long-acting intramuscular delivery of curcumin didecanoate prodrug: preparation, characterization and in vivo evaluation. Wei XL, Han YR, Et al. Eur J Pharm Sci. 2013 May 13;49(2):286-93. doi: 10.1016/j.ejps.2013.03.010. Epub 2013 Mar 29.
- Curcumin loaded nano globules for solubility enhancement: preparation, characterization and ex vivo release study. Kumar A, Ahuja A, Ali J, Baboota S. J Nanoscience Nanotechnology. 2012 Nov;12(11):8293-302.
- SNEDDS curcumin formulation leads to enhanced protection from pain and functional deficits associated with diabetic neuropathy: an insight into its mechanism for neuroprotection. Joshi RP, Et al. Nanomedicine. 2013 Aug;9(6):776-85. doi: 10.1016/j.nano.2013.01.001.
- Recent progress in studying curcumin and its nano-preparations for cancer therapy. Liu J, Et al. Curr Pharm Des. 2013;19(11):1974-93. Review.
- Preparation and characterization of cationic curcumin nanoparticles for improvement of cellular uptake. Liu J, Xu L, Et al. Carbohydr Polym. 2012 Sep 1;90(1):16-22.
- In situ injectable nano-composite hydrogel composed of curcumin, N,O-carboxymethyl chitosan and oxidized alginate for wound healing application. Li X, Et al. Int J Pharm. 2012 Nov 1;437(1-2):110-9. doi: 10.1016/j.ijpharm.2012.08.001.
- Forming of demethoxycurcumin nanocrystallite-chitosan nanocarrier for controlled low dose cellular release for inhibition of the migration of vascular smooth muscle cells. Wang YJ, Lin HY, Wu CH, Liu DM. Mol Pharm. 2012 Aug 6;9(8):2268-79. doi: 10.1021/mp300150q.
- Versatile and efficient targeting using a single nanoparticulate platform: application to cancer and Alzheimer’s disease. Le Droumaguet B, Et al. ACS Nano. 2012 Jul 24;6(7):5866-79.
- Enhancement of cellular uptake and cytotoxicity of curcumin-loaded PLGA nanoparticles by conjugation with anti-P-glycoprotein in drug resistance cancer cells. Punfa W, ET al.Acta Pharmacol Sin. 2012 Jun;33(6):823-31. doi: 10.1038/aps.2012.34. Epub 2012 May 14.
- Hybrid fluorescent curcumin loaded zein electrospun nanofibrous scaffold for biomedical applications. Brahatheeswaran D, Et al. Biomed Mater. 2012 Aug;7(4):045001. doi: 10.1088/1748-6041/7/4/045001.
- Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation. Yan JW, Et al. Bioorg Med Chem. 2012 Apr 15;20(8):2527-34. doi: 10.1016/j.bmc.2012.02.061.
- Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer’s disease. Mathew A, Et al.
- Validity of silver, chitosan, and curcumin nanoparticles as anti-Giardia agents. Said DE, Elsamad LM, Gohar YM. Parasitol Res. 2012 Aug;111(2):545-54. doi: 10.1007/s00436-012-2866-1.
- Contribution of formulation and excipients towards enhanced permeation of curcumin. Wahlang B, Et al. 2012 Feb;62(2):88-93.
- Comparison of two encapsulated curcumin particular systems contained in different formulations with regard to in vitro skin penetration. Suwannateep N, Et al. Skin Res Technol. 2013 Feb;19(1):1-9.
- Nanocapsulated curcumin: oral chemopreventive formulation against diethylnitrosamine induced hepatocellular carcinoma in rat. Ghosh D, Et al. Chem Biol Interact. 2012 Feb 5;195(3):206-14.
- Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent. Dev S, Et al. Nanoscale. 2012 Apr 21;4(8):2575-9. doi: 10.1039/c2nr11502f.
- Controlled release pulmonary administration of curcumin using swellable biocompatible microparticles. El-Sherbiny IM, Smyth HD. Mol Pharm. 2012 Feb 6;9(2):269-80.
- Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice. Zhongfa L, Et al. Cancer Chemother Pharmacol. 2012 Mar;69(3):679-89.
- Curcumin-loaded apotransferrin nanoparticles provide efficient cellular uptake and effectively inhibit HIV-1 replication in vitro. Gandapu U, Chaitanya RK, Et al. PLoS One. 2011;6(8):e23388. doi: 10.1371/journal.pone.0023388.
- Optimised nano-formulation on the bioavailability of hydrophobic polyphenol, curcumin, in freely-moving rats. Tsai YM, Jan WC, Et al. Food Chem. 2011 Aug 1;127(3):918-25.
- Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration. Tsai YM, Chien CF, Lin LC, Tsai TH. Int J Pharm. 2011 Sep 15;416(1):331-8.
- Biocompatible, biodegradable and thermo-sensitive chitosan-g-poly (N-isopropylacrylamide) nanocarrier for curcumin drug delivery. Rejinold NS,Et al. Int J Biol Macromol. 2011 Aug 1;49(2):161-72.
- Innovative preparation of curcumin for improved oral bioavailability. Sasaki H, Et al. Biol Pharm Bull. 2011;34(5):660-5.
- Investigations on the interaction of gold-curcumin nanoparticles with human peripheral blood lymphocytes. Sindhu K, Et al. J Biomed Nanotechnol. 2011 Feb;7(1):56.
- Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells. Pandey MK, Et al. Eur J Pharm Sci. 2011 May 18;43(1-2):16-24.
- Curcumin nanoparticles: preparation, characterization, and antimicrobial study. Bhawana, Et al. J Agric Food Chem. 2011 Mar 9;59(5):2056-61.
- Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo. Gou M, Et al. Nanoscale. 2011 Apr;3(4):1558-67.
- Indian gold treating cancer in the age of nano. Tuttle S, Hertan L, Katz JS. Cancer Biol Ther. 2011 Mar 1;11(5):474-6.
- Curcumin-decorated nanoliposomes with very high affinity for amyloid-β1-42 peptide. Mourtas S, Et al. Biomaterials. 2011 Feb;32(6):1635-45.
- Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer. Nair HB, Et al, Biochem Pharmacol. 2010 Dec 15;80(12):1833-43.
- Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells. Yallapu MM, Gupta BK, Jaggi M, Chauhan SC. J Colloid Interface Sci. 2010 Nov 1;351(1):19-29.
- Toxicological evaluation of pH-sensitive nanoparticles of curcumin: acute, sub-acute and genotoxicity studies. Dandekar P, Et al. Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2073-89.
- Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth. Yallapu MM, Et al. J Ovarian Res. 2010 Apr 29;3:11.
- Characterization and cytotoxicity of self-organized assemblies of curcumin and amphiphatic poly(ethylene glycol). Sou K, Et al. J Biomed Nanotechnol. 2009 Apr;5(2):202-8.